AICAR 50mg 10vials

Description

AICAR >99% Purity | AMPK Activator Nucleoside

Product Specifications

• CAS Number: 2627-69-2
• Molecular Formula: C9H14N4O5
• Molecular Weight: 258.23 Da
• Purity: >99.0% via HPLC-UV and Mass Spectrometry
• Appearance: Fine white sterile lyophilizate

Mode of Action

The biochemical activity of AICAR is defined by its intracellular conversion into ZMP (5-aminoimidazole-4-carboxamide ribonucleotide). The primary mechanism involves upon entering the cell, AICAR is phosphorylated by adenosine kinase to form ZMP. This defines the first semantic triple: [AICAR converts to ZMP]. Following this, ZMP acts as a structural analog of Adenosine Monophosphate (AMP), binding directly to the ??-subunit of the AMPK heterotrimer. This establishes the second triple: [ZMP mimics AMP signaling]. Furthermore, this binding induces a conformational change that promotes the phosphorylation of the ??-subunit at Thr172, thereby activating the AMPK complex. This forms the third triple: [AICAR triggers AMPK activation]. Quantitatively, this activation stimulates the translocation of GLUT4 to the cell membrane, enhancing glucose uptake independent of insulin. Research indicates that AICAR-mediated AMPK activation can increase mitochondrial protein expression by up-regulating the PGC-1?? transcriptional coactivator.

Compound Background

AICAR (5-Aminoimidazole-4-carboxamide ribonucleoside), also known as Acadesine, is a cell-permeable nucleoside analog that functions as a potent activator of AMP-activated protein kinase (AMPK). In biological systems, it mimics the effects of cellular energy depletion, effectively “tricking” the cell into a state of energetic stress. This signaling molecule is a cornerstone in research investigating metabolic remodeling, mitochondrial biogenesis, and the molecular pathways of physical endurance. [AICAR activates AMPK].

Reported Findings

• Enhanced Metabolic Endurance: Users report significant increases in aerobic capacity and “endurance-mimetic” effects in sedentary research models.
• Accelerated Fat Oxidation: Published research indicates a marked reduction in lipid storage through the inhibition of acetyl-CoA carboxylase (ACC).
• Insulin-Independent Glucose Uptake: Per experimental records, AICAR maintains glucose homeostasis even in states of insulin resistance.
• Anti-Inflammatory Signaling: Research models demonstrate a reduction in pro-inflammatory cytokines like TNF-?? and IL-6 via the modulation of NF-??B pathways.
• Vascular Perfusion Support: Multiple research groups note improved blood flow and nitric oxide (NO) production in ischemic tissue models.

Key Points:
AICAR represents a premier research tool for investigating the master regulation of energy metabolism and the pharmacological induction of endurance-like adaptations.

Frequently Asked Questions

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult a qualified healthcare professional before use.