CJC-1295 without DAC 10mg *10 Vials*1 Kit- Best Eeffect Hiqh Purity Peptides Product
Original price was: $500.00.$220.00Current price is: $220.00.
CJC-1295 without DAC (Modified GRF 1-29) is a tetrasubstituted GHRH analog engineered to stimulate natural, pulsatile growth hormone secretion from the anterior pituitary. Its 30-minute half-life mimics physiological GH rhythms without pituitary receptor downregulation.
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Description
CJC-1295 without DAC GHRH Analog Growth Hormone Research Peptide
About This Compound
CJC-1295 without DAC, frequently identified in scientific literature as Modified GRF 1-29, is a structurally modified synthetic analog of endogenous Growth Hormone-Releasing Hormone. This tetrasubstituted peptide is specifically engineered to stimulate the somatotroph cells of the anterior pituitary gland, prompting a natural, pulsatile secretion of growth hormone without disrupting the body’s intrinsic physiological rhythms.
Specification Sheet
- Sequence Modification: 29-amino acid chain with 4 distinct substitutions to prevent rapid cleavage
- Molecular Formula: C152H252N44O42
- Molecular Weight: ~3367.9 g/mol
- Purity: >99% (HPLC validated)
- Appearance: Sterile filtered white lyophilized powder
Mode of Action
CJC-1295 without DAC binds with high affinity to GHRH receptors on the anterior pituitary, initiating a cyclic AMP (cAMP) dependent intracellular signaling cascade. Because it lacks the Drug Affinity Complex (DAC)??a modification that binds to blood albumin??this compound exhibits a brief pharmacokinetic half-life of approximately 30 ?? 5 minutes. This rapid clearance is highly advantageous for researchers aiming to mimic a natural, physiological GH pulse rather than an unnatural continuous elevation. By triggering acute spikes, the compound inherently avoids the down-regulation of pituitary receptors and preserves the negative feedback loop mediated by somatostatin.
Research Observations
- Study findings show a significant increase in slow-wave, deep sleep quality.
- Published research indicates enhanced systemic lipolysis and shifts in body composition.
- Aggregated data shows accelerated recovery from musculoskeletal fatigue and training.
- Researchers note observable improvements in skin elasticity and collagen synthesis over sustained periods.
Key Points:
CJC-1295 without DAC is a precise, short-acting research peptide ideal for stimulating natural, episodic bursts of growth hormone without causing receptor down-regulation.
Frequently Asked Questions
[Q] What does ‘without DAC’ mean?
It means the peptide lacks the Drug Affinity Complex, resulting in a short 30-minute half-life rather than a prolonged multi-day release.
[Q] How often should this peptide be administered?
Due to the short half-life, users typically report administering this compound 1 to 3 times daily to mimic natural pulses.
[Q] Should I inject this with food?
No, community consensus strongly recommends administering on an empty stomach, as elevated insulin or free fatty acids can blunt the pulse.
[Q] Why do users experience facial flushing?
Flushing is a common, harmless physiological reaction to the sudden vasodilation triggered by GHRH analogs immediately after administration.
[Q] Can this be combined with a GHRP?
Yes, researchers frequently observe a synergistic effect when GHRH analogs are combined with a GHRP like Ipamorelin or GHRP-6 Acetate.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult a qualified healthcare professional before use.
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