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Melatonin 10mg 10 Vials

Melatonin 10mg 10 Vials

Original price was: $220.00.Current price is: $110.00.

Melatonin is a fundamental circadian hormone that activates MT1 and MT2 receptors in the suprachiasmatic nucleus to regulate sleep-wake cycles and phase-shift circadian rhythms. Additionally, it acts as a direct free radical scavenger without requiring enzymatic catalysis.

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Description

Melatonin 10mg Circadian Rhythm & Sleep Regulation Research

How It Works

The biochemical activity of Melatonin is mediated through high-affinity G-protein coupled receptors (GPCRs) and direct non-receptor-mediated pathways. Initially, the molecule binds to the MT1 receptor in the Suprachiasmatic Nucleus (SCN), inhibiting neuronal firing to promote sleep-wake transition. This defines the first semantic triple: [Melatonin activates MT1 receptors]. Following this, it engages the MT2 receptor to facilitate the “phase-shifting” of the circadian rhythm. This establishes the second triple: [MT2 activation regulates circadian phase]. Thirdly, due to its high electron-donating capacity, Melatonin directly neutralizes reactive oxygen and nitrogen species (ROS/RNS) without requiring a catalyst. This forms the third triple: [Melatonin scavenges free radicals]. Quantitatively, Melatonin demonstrates a systemic half-life of approximately 20 to 45 minutes in humans. Unlike traditional sedative-hypnotics, Melatonin organizes the architecture of sleep rather than merely inducing CNS depression.

Specification Sheet

  • CAS Number: 73-31-4
  • Molecular Formula: C13H16N2O2
  • Molecular Weight: 232.28 Da
  • Purity: >99.0% via HPLC-UV and Mass Spectrometry
  • Appearance: Crystalline white sterile lyophilizate

Experimental Outcomes

  • Circadian Resynchronization: Users in research models report significant reductions in sleep latency and improved adaptation to phase-shift stressors.
  • Mitochondrial Protection: Controlled trials show enhanced mitochondrial respiration and a reduction in cytochrome c release under oxidative stress.
  • Neuroprotective Signaling: As documented in protocols, research models show reduced biomarkers of neuroinflammation in age-related cognitive decline studies.
  • Immunomodulatory Action: Aggregated data shows a stabilizing effect on cytokine production, potentially acting as a “buffering” agent for the immune system.
  • Oncostatic Research Potential: Specialized models have observed an ability to inhibit the uptake of linoleic acid in certain cellular clusters.

Product Profile

Melatonin (N-acetyl-5-methoxytryptamine) is a ubiquitous signaling molecule synthesized primarily in the pineal gland from the precursor tryptophan. Functioning as the “master clock” of the mammalian system, it translates the environmental light-dark cycle into a systemic endocrine signal. Beyond its chronobiological role, Melatonin is a potent, amphiphilic antioxidant capable of crossing all biological barriers, including the blood-brain barrier.
Key Points:
Melatonin represents a fundamental research tool for investigating the intersection of chronobiology, mitochondrial bioenergetics, and systemic antioxidant defense.

Frequently Asked Questions

How long does Melatonin stay in the system?

Melatonin has a short biological half-life of about 30 to 50 minutes, meaning it is cleared from the bloodstream relatively quickly.

Is high-dose Melatonin safe for research?

While standard doses are 1-5mg, research into antioxidant and cancer models often uses much higher doses with a high safety margin.

Why is my Melatonin vial not dissolving in water?

Melatonin is lipophilic; it requires a small amount of a solvent like ethanol or DMSO before it can be diluted into a water-based solution.

Does Melatonin affect other hormones?

In high-dose research models, it may have transient effects on the HPG axis, but it does not suppress hormones like testosterone in standard sleep models.

What is the best way to store the powder?

It must be kept in a cool, dry, and dark place. Exposure to light will cause the hormone to degrade and lose its blue-white fluorescence.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult a qualified healthcare professional before use.

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