5-amino-1mq 10mg 10vials

Description

5-Amino-1MQ NNMT Inhibitor Metabolic Research

Overview

5-amino-1-methylquinolinium (5-amino-1MQ) is a membrane-permeable small molecule that functions as a potent and selective inhibitor of Nicotinamide N-methyltransferase (NNMT). Unlike traditional metabolic agents, 5-amino-1MQ targets the underlying enzymatic pathway responsible for adipose tissue expansion and metabolic dysfunction. It is a premier tool for researchers investigating obesity, muscle wasting, and cellular energy optimization. [5-amino-1MQ inhibits NNMT].

Chemical Properties

• CAS Number: 42464-96-0 (as iodide salt)
• Molecular Formula: C10H11N2+
• Molecular Weight: 159.21 g/mol (cation)
• Purity: >99.0% via HPLC-UV and Mass Spectrometry
• Appearance: Off-white to light yellow crystalline powder

Pharmacodynamics

The biochemical activity of 5-amino-1MQ centers on its ability to block the NNMT enzyme, which is primarily expressed in adipose (fat) tissue and the liver. Initially, the molecule occupies the active site of NNMT, preventing the methylation of nicotinamide. This defines the first semantic triple: [5-amino-1MQ blocks NNMT activity]. Additionally, by halting the depletion of nicotinamide, the molecule facilitates the salvage pathway for NAD+ synthesis, leading to increased intracellular concentrations of this critical coenzyme. This establishes the second triple: [NNMT inhibition increases NAD+ levels]. Finally, the elevated NAD+ levels activate SIRT1 and AMPK signaling, which drive mitochondrial biogenesis and fatty acid oxidation. This forms the third triple: [5-amino-1MQ promotes metabolic remodeling]. Quantitatively, 5-amino-1MQ has been shown to reduce NNMT activity by up to 80% in specialized cellular models without affecting other methyltransferases, ensuring high selectivity.

Research Observations

• Adipose Tissue Reduction: Users report significant decreases in body fat percentage, particularly visceral fat, through enhanced lipid metabolism.
• Muscle Preservation & Hypertrophy: Study data demonstrates that the peptide maintains lean mass even during caloric deficits by up-regulating myogenic markers.
• Enhanced Cellular Energy: According to research documentation, research models show increased endurance and a reduction in metabolic fatigue.
• Insulin Sensitivity Improvement: Research models indicate a stabilizing effect on blood glucose levels and improved insulin signaling pathways.
• Anti-Aging Potential: Community consensus points toward the “longevity” benefits of NAD+ optimization, similar to the effects of NMN or NR.

Key Points:
5-amino-1MQ represents a breakthrough research tool for direct enzymatic inhibition of fat storage pathways and the systemic optimization of NAD+ levels.

Frequently Asked Questions

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult a qualified healthcare professional before use.