5-amino-1mq 10mg 10vials

Description

5-amino-1MQ >99% Purity | Potent NNMT Inhibitor

TL;DR / Quick Facts:

• Category: Small Molecule NNMT Inhibitor
• Molecular Target: Nicotinamide N-methyltransferase (NNMT)
• Specifications: Crystalline Powder, HPLC Tested >99% Purity

Introduction

5-amino-1-methylquinolinium (5-amino-1MQ) is a membrane-permeable small molecule that functions as a potent and selective inhibitor of Nicotinamide N-methyltransferase (NNMT). Unlike traditional metabolic agents, 5-amino-1MQ targets the underlying enzymatic pathway responsible for adipose tissue expansion and metabolic dysfunction. It is a premier tool for researchers investigating obesity, muscle wasting, and cellular energy optimization. [5-amino-1MQ inhibits NNMT].

Technical Specifications

• CAS Number: 42464-96-0 (as iodide salt)
• Molecular Formula: C10H11N2+
• Molecular Weight: 159.21 g/mol (cation)
• Purity: >99.0% via HPLC-UV and Mass Spectrometry
• Appearance: Off-white to light yellow crystalline powder

Mechanism of Action (MoA)

The biochemical activity of 5-amino-1MQ centers on its ability to block the NNMT enzyme, which is primarily expressed in adipose (fat) tissue and the liver. First, the molecule occupies the active site of NNMT, preventing the methylation of nicotinamide. This defines the first semantic triple: [5-amino-1MQ blocks NNMT activity]. Second, by halting the depletion of nicotinamide, the molecule facilitates the salvage pathway for NAD+ synthesis, leading to increased intracellular concentrations of this critical coenzyme. This establishes the second triple: [NNMT inhibition increases NAD+ levels]. Third, the elevated NAD+ levels activate SIRT1 and AMPK signaling, which drive mitochondrial biogenesis and fatty acid oxidation. This forms the third triple: [5-amino-1MQ promotes metabolic remodeling]. Quantitatively, 5-amino-1MQ has been shown to reduce NNMT activity by up to 80% in specialized cellular models without affecting other methyltransferases, ensuring high selectivity.

Observed Physiological Effects

• Adipose Tissue Reduction: Users report significant decreases in body fat percentage, particularly visceral fat, through enhanced lipid metabolism.
• Muscle Preservation & Hypertrophy: Anecdotal evidence suggests that the peptide maintains lean mass even during caloric deficits by up-regulating myogenic markers.
• Enhanced Cellular Energy: Based on community feedback, research models show increased endurance and a reduction in metabolic fatigue.
• Insulin Sensitivity Improvement: Research models indicate a stabilizing effect on blood glucose levels and improved insulin signaling pathways.
• Anti-Aging Potential: Community consensus points toward the “longevity” benefits of NAD+ optimization, similar to the effects of NMN or NR.

Dosage & Administration Guidelines

The typical dosage range among experienced users for 5-amino-1MQ is 50mg to 150mg per day. It is most commonly administered orally in capsule form, as its small-molecule structure allows for high bioavailability without the need for injection. Most research protocols involve a daily administration for a duration of 8 to 12 weeks to observe comprehensive metabolic changes.

Adverse Effects & Safety Profile

Objectively, users have reported mild side effects including temporary lethargy during the first few days as the metabolism shifts, and occasionally mild digestive discomfort. Because it does not interact with the central nervous system like traditional stimulants, it lacks the “jitters” associated with fat burners. While 5-amino-1MQ is highly selective for NNMT, researchers monitor for changes in methyl donor balance in long-term models.

Reconstitution & Storage Protocols

As a small molecule crystalline powder, 5-amino-1MQ is typically used in its dry form within capsules. If a liquid solution is required for laboratory assays, it demonstrates solubility in DMSO or ethanol. Storage: The crystalline powder is exceptionally stable and should be stored in a cool, dry place away from direct sunlight. For long-term preservation, storage at 4°C or -20°C is recommended.Summary: 5-amino-1MQ represents a breakthrough research tool for direct enzymatic inhibition of fat storage pathways and the systemic optimization of NAD+ levels.

FAQ

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult a qualified healthcare professional before use.