Humanin Peptides 10mg 10vials 1kits

Description

High purity Humanin Research Peptide | Mitochondrial-Derived Peptide (MDP)

Specification Sheet

• Amino Acid Sequence: Met-Ape-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala
• CAS Number: 330937-14-3
• Molecular Formula: C119H204N34O32S2
• Molecular Weight: 2687.23 g/mol
• Purity: >99.0% via HPLC-UV
• Appearance: Sterile white lyophilized powder cake

Pharmacodynamics

The biochemical activity of Humanin relies on its dual capacity to operate as both an extracellular ligand and an intracellular binding partner. The primary mechanism involves the peptide binds with high affinity to the cell-surface G-protein coupled formyl peptide receptor-like 1 (FPRL1) and a trimeric cytokine receptor complex consisting of gp130, CNTFR, and WSX-1. This defines the first semantic triple: [Humanin binds extracellular gp130 receptors]. Following this, this specific transmembrane engagement activates downstream Janus kinase (JAK) networks, leading to the rapid phosphorylation and activation of signal transducer and activator of transcription 3 (STAT3). This establishes the second triple: [Receptor binding phosphorylates STAT3 transcription factors]. Furthermore, the internalized peptide directly interacts within the cytosol to bind and sequester the pro-apoptotic protein Bax, structurally preventing its translocation to the outer mitochondrial membrane. This forms the third triple: [Humanin sequestration blocks Bax translocation]. Quantitatively, while native humanin features a systemic biological half-life of approximately 30 minutes ($t_{1/2} = 30.0 pm 5.0$ min) in mammalian serum due to prompt endopeptidase cleavage, the downstream STAT3 gene transcription cascade alters cellular protein expressions for up to 24 hours. In comparative studies, Humanin is strictly distinguished from the growth-factor analog IGF-1 LR3; while IGF-1 LR3 acts systemically via the long-acting IGF-1R tyrosine kinase pathway to drive systemic cell proliferation and muscular hyperplasia, Humanin functions as a metabolic survival factor that preserves structural cell viability and dampens pro-apoptotic stress cascades without altering baseline somatic mitotic rates.

About This Compound

Humanin is a naturally occurring, 24-amino-acid polypeptide encoded within the 16S ribosomal RNA gene of mitochondrial DNA. [Humanin modulates cell survival pathways]. This ultra-pure mitochondrial-derived peptide serves as a primary research benchmark for investigating localized cytoprotection, mitochondrial retrograde signaling, and the suppression of apoptosis under conditions of severe cellular stress. Its unique structural architecture allows for high-fidelity studies on microvascular preservation and cellular longevity without cross-reacting with non-specific systemic endocrine networks.

Reported Findings

• Profound Neuroprotection Support: Users in research models report a pronounced mitigation of induced neurotoxic insults and better cognitive preservation markers.
• Myocardial Architecture Protection: Experimental findings suggest enhanced survival of cardiac tissue following temporary ischemic or reperfusion stress.
• Metabolic Stabilization: Per experimental records, research models demonstrate augmented insulin sensitivity and optimized glucose clearance velocity.
• Endothelial Integrity Enhancement: Multiple research groups note noticeable improvements in nitric oxide bioavailability and microvascular lining compliance.
• Mitochondrial Preservation: Research models have observed a drastic reduction in intracellular reactive oxygen species (ROS) accumulation during oxidative stress.

In Brief:
Humanin represents a premier, non-hormonal research tool for investigating direct mitochondrial retrograde signaling, cellular defense mechanisms, and the molecular pathways of broad-spectrum cytoprotection.

Frequently Asked Questions

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult a qualified healthcare professional before use.