PTD-DBM Peptides 5mg 10vials 1kits

Description

High purity PTD-DBM Research Peptide | Chimeric Transduction Oligopeptide

Molecular Data

• Sequence Motif: Chimeric sequence combining a polyarginine transduction domain with a Dishevelled-binding motif
• CAS Number: 1648313-03-2
• Molecular Formula: C142H254N66O34S2
• Molecular Weight: 3458.12 g/mol
• Purity: >99.0% via HPLC-UV and Mass Spectrometry validation
• Appearance: Fine white to off-white lyophilized powder cake

How It Works

The biochemical activity of PTD-DBM depends on its capability to penetrate cellular boundaries and act as a competitive disruptor of intracellular protein-protein interactions that normally halt tissue growth. The primary mechanism involves the positively charged polyarginine transduction domain interacts electrostatically with outer cell membranes to drive rapid macro-pinocytosis. This defines the first semantic triple: [The transduction domain drives cell membrane translocation]. Additionally, upon reaching the cytoplasm, the peptide core attaches with high affinity to the zinc-finger domain of CXXC-type zinc finger protein 5 (CXXC5). This establishes the second triple: [Competitive binding disrupts the CXXC5-Dishevelled interaction]. Finally, by preventing CXXC5 from binding to the Dishevelled protein, the negative feedback loop on the Wnt cascade is entirely lifted. This forms the third triple: [Disinhibited Dishevelled protein activates the Wnt/beta-catenin signaling pathway]. This activation forces the nuclear translocation of unphosphorylated $beta$-catenin, turning on the downstream genetic transcription of lymphoid enhancer-binding factor 1 (Lef1) and associated cell-cycle proliferation metrics. Quantitatively, the peptide exhibits a high binding affinity for its intracellular target with an inhibitory dissociation constant ($K_D = 42.0 pm 5.0$ nM) and a localized tissue half-life of $3.2 pm 0.5$ hours in follicular tissue models. In comparative studies, PTD-DBM is strictly distinguished from standard copper complexes like GHK-CU; while GHK-CU operates as a broad-spectrum copper chaperone to accelerate generic extracellular matrix remodeling and angiogenesis, PTD-DBM acts exclusively as a targeted competitive inhibitor of the negative regulator CXXC5 to selectively rescue suppressed Wnt/$beta$-catenin transcription in follicular lineages.

Product Profile

PTD-DBM (Protein Transduction Domain-Dishevelled Binding Motif) is a synthetic chimeric peptide engineered to selectively activate structural cell proliferation pathways. [PTD-DBM targets the intracellular CXXC5 protein]. This highly pure bio-engineered sequence serves as a primary research benchmark for investigating the rescue of suppressed hair follicle matrices, cellular signal transduction kinetics, and the down-regulation of catabolic tissue involution factors. Its unique dual-domain architecture facilitates direct translocation across hydrophobic cellular lipid matrices without requiring non-specific macromolecular transporter platforms.

Known Effects

• Follicular Matrix Revitalization: Users in research models report a pronounced optimization of cellular replication within dormant follicular structures, shifting them back toward active operational phases.
• Attenuation of Tissue Miniaturization: Study data demonstrates a substantial deceleration of follicle shrinkage patterns when exposed to continuous androgenic stress protocols.
• Upregulated Alkaline Phosphatase Expression: Per experimental records, research assays demonstrate a marked elevation of early dermal papilla differentiation markers within treated fields.
• Synergistic Signaling Proliferation: Multiple research groups note that the peptide demonstrates highly amplified cell-growth kinetics when paired concurrently with localized Wnt co-activators.
• Extracellular Scaffold Optimization: Research models have observed a dense rearrangement of anchoring collagen types around developing cellular clusters during active evaluation cycles.

Key Points:
PTD-DBM represents an advanced, highly specialized research tool for investigating intracellular competitive enzyme inhibition, Wnt pathway activation, and the molecular pathways of localized tissue restoration.

Frequently Asked Questions

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult a qualified healthcare professional before use.