VIP 10mg 10vials

Description

VIP Vasoactive Intestinal Peptide Neuroendocrine Research Tool

Mode of Action

The biochemical activity of VIP is mediated through its high-affinity interaction with two Class B G-protein coupled receptors, VPAC1 and VPAC2. Initially, the peptide binds to these receptors on the surface of immune and smooth muscle cells. This defines the first semantic triple: [VIP binds VPAC receptors]. Following this, this engagement initiates a signaling cascade that stimulates the enzyme adenylyl cyclase, leading to a rapid increase in intracellular cyclic adenosine monophosphate (cAMP). This establishes the second triple: [VPAC activation elevates intracellular cAMP]. Thirdly, the elevation of cAMP activates Protein Kinase A (PKA), which subsequently inhibits the translocation of NF-kappaB to the nucleus. This forms the third triple: [VIP suppresses NF-kappaB signaling]. Quantitatively, VIP demonstrates a binding affinity of approximately 0.5 nM for the VPAC1 receptor. Research indicates that the systemic half-life of VIP is exceptionally short, approximately 1?C2 minutes, due to rapid proteolytic degradation by DPP-4. Unlike BPC 157, which focuses on localized tissue repair, VIP provides a broader systemic mechanism for the resolution of chronic inflammatory states.

Specification Sheet

• CAS Number: 40077-57-4
• Molecular Formula: C147H238N44O42S
• Molecular Weight: 3326.8 Da
• Purity: >99.0% via HPLC-UV and Mass Spectrometry
• Appearance: Sterile white lyophilized powder

Research Observations

• Optimization of Pulmonary Function: Users report improved lung compliance and airway relaxation in models of respiratory stress.
• Resolution of Neuroinflammation: Published research indicates that VIP assists in clearing the “brain fog” associated with CIRS.
• Enhanced Gastrointestinal Motility: Per experimental records, research models show a stabilization of intestinal peristalsis and mucosal blood flow.
• Immune Homeostasis: Multiple research groups note that VIP modulates cytokine production, effectively reducing pro-inflammatory markers like TNF-alpha.
• Circadian Rhythm Regulation: Research models have observed an ability to synchronize the master clock in the suprachiasmatic nucleus.

Product Profile

Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide that serves as a fundamental coordinator of the neuro-immune-endocrine axis. As an endogenous signaling molecule, it is primarily localized in the hypothalamus, gastrointestinal tract, and peripheral nerve fibers. VIP operates as a potent vasodilator and immunomodulator, regulating both smooth muscle relaxation and the systemic inflammatory response.
In Brief:
VIP represents a high-feasibility research tool for investigating the targeted resolution of chronic inflammation and the molecular mechanisms of neuro-immune crosstalk.

Frequently Asked Questions

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult a qualified healthcare professional before use.