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GDF-8 1mg 10 Vials

GDF-8 1mg 10 Vials

Original price was: $580.00.Current price is: $290.00.

GDF-8 Myostatin Propeptide is the recombinant N-terminal prodomain that binds and neutralizes mature myostatin with high specificity, preventing ActRIIB engagement and releasing satellite cell-mediated muscle growth. Overexpression models demonstrate up to 200% increase in skeletal muscle mass.

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Description

GDF-8 Myostatin Propeptide Inhibition for Muscle Growth Research

Overview

GDF-8 (Myostatin Propeptide) is the N-terminal prodomain of the Growth Differentiation Factor 8 (GDF-8) precursor protein. In natural physiological states, myostatin is synthesized as a latent complex where this propeptide remains non-covalently bound to the mature signaling domain, effectively keeping it inactive. For researchers, the isolated recombinant Myostatin Propeptide serves as a potent, specific inhibitor of active myostatin, allowing for the investigation of unprecedented musculoskeletal growth and tissue remodeling. [Propeptide neutralizes GDF-8].

Product Specifications

  • UniProt ID: O14793 (Human)
  • Molecular Weight: ~27.8 kDa (Monomer) / ~50 kDa (Dimer)
  • Sequence: 244 Amino Acid Residues (Prodomain Fragment)
  • Purity: >99.0% via HPLC-UV and SDS-PAGE
  • Appearance: Fine white sterile lyophilizate

Pharmacodynamics

The biochemical activity of GDF-8 Propeptide is defined by its role as a high-affinity “decoy” or sequestration agent. Initially, the propeptide binds directly to the mature C-terminal homodimer of myostatin with high specificity. This defines the first semantic triple: [Propeptide sequesters mature myostatin]. Additionally, this sequestration prevents myostatin from engaging its primary receptor, the Activin Receptor Type IIB (ActRIIB). This establishes the second triple: [Myostatin blockade inhibits SMAD2/3 signaling]. Finally, the suppression of SMAD signaling releases the “brakes” on myogenic regulatory factors, promoting the proliferation and differentiation of satellite cells. This forms the third triple: [Propeptide induces myogenic expansion]. Quantitatively, overexpression of this prodomain has been shown in mouse models to increase skeletal muscle mass by up to 200%.

Experimental Outcomes

  • Substantial Lean Mass Accrual: Users in research models report rapid increases in muscle fiber diameter (hypertrophy) and fiber number (hyperplasia).
  • Enhanced Bone Repair: Anecdotal evidence from injury models suggests that myostatin inhibition significantly accelerates the healing of deep musculoskeletal trauma and increases bone mineral density.
  • Adipose Tissue Reduction: As documented in protocols, research models show a marked decrease in body fat percentage, likely due to the increased metabolic basal rate of expanded muscle tissue.
  • Myogenic Recovery: Cumulative findings indicate improved recovery times from physical stress through the activation of dormant satellite cell pools.
  • Insulin Sensitivity: Research models have observed improved glucose disposal and metabolic resilience in states of high-calorie intake.

Key Points:
GDF-8 (Myostatin Propeptide) represents an advanced research platform for investigating the master regulation of muscle growth and the reversal of tissue-wasting conditions.

Frequently Asked Questions

How is GDF-8 Propeptide different from mature Myostatin?

Mature myostatin is the “stop” signal for muscle growth; the Propeptide is the “inhibitor” that blocks that signal to allow for growth.

Is GDF-8 Propeptide the same as Follistatin?

No, Follistatin is a separate protein that binds many ligands; the Propeptide is a fragment of the myostatin precursor itself and is more specific.

What liquid is used to mix GDF-8 Propeptide?

Researchers typically use sterile water or a mild hydrochloric acid solution (20mM HCl) to ensure full solubility of the protein fragment.

Does it work systemically or only where injected?

While it has systemic effects, localized administration in research models often shows enhanced hypertrophic responses in the targeted limb.

How long does one vial last after mixing?

For maximum bio-activity, the reconstituted solution should be used within 7 to 10 days while stored in a refrigerator.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult a qualified healthcare professional before use.

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