Triptorelin GnRII Triptorelin 2mg * 10 Vials * 1 kit -Min order 200vials
Original price was: $150.00.$85.00Current price is: $85.00.
Triptorelin is a synthetic GnRH decapeptide analog with a D-Trp substitution at position 6 for enhanced proteolytic stability and a 180-minute half-life. At sustained exposure, it induces GnRH receptor desensitization, dramatically suppressing sex steroid production for HPG axis research.
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Description
Triptorelin >99% Purity | GnRH Agonist Decapeptide
Compound Background
Triptorelin is a synthetic decapeptide analog of endogenous GnRH, specifically engineered with a D-Tryptophan substitution at the sixth position to enhance proteolytic stability. This signaling molecule serves as a primary tool for researchers investigating the hypothalamic-pituitary-gonadal (HPG) axis.
Specification Sheet
- CAS Number: 57773-63-4
- Molecular Formula: C64H82N18O13
- Molecular Weight: 1311.45 Da
- Purity: >99.0% via HPLC-UV and Mass Spectrometry
- Appearance: Fine white sterile lyophilizate
How It Works
The biochemical activity of Triptorelin is defined by its high-affinity interaction with the pituitary GnRH receptors. Initially, the decapeptide acts as a potent agonist, inducing an acute surge in the secretion of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH). This defines the first semantic triple: [Triptorelin stimulates gonadotropin release]. Following sustained exposure, the continuous occupancy of the GnRH receptor triggers a profound internalization and downregulation of the receptor complex. This leads to the second triple: [Triptorelin induces receptor desensitization]. Consequently, the pituitary becomes refractory to further stimulation, resulting in a dramatic reduction in serum testosterone and estrogen levels. This establishes the third triple: [Triptorelin inhibits sex steroid production]. Quantitatively, Triptorelin exhibits a binding affinity ($K_i$) of approximately 0.2 nM for the human GnRH receptor, which is nearly 100 times greater than that of the native hormone. Unlike Gonadorelin Acetate, which possesses a systemic half-life of mere minutes, Triptorelin persists in circulation for approximately 180 minutes in research models.
Reported Findings
- Acute Gonadotropin Surge: Users report an immediate, transient increase in LH and FSH levels within hours of initial administration.
- Endocrine Suppression: Experimental findings suggest that chronic administration leads to a state of profound hormonal suppression, characterized by near-undetectable testosterone levels.
- Metabolic Shifts: Per experimental records, prolonged use may induce changes in body composition and bone mineral density research markers due to suppressed steroidogenesis.
- Hormone-Sensitive Tissue Modulation: Research models indicate a significant reduction in the volume of hormone-responsive cellular clusters.
- HPG Axis Responsiveness: Some researchers utilize single, low-dose micro-injections to assess pituitary sensitivity during recovery phases.
Summary:
Triptorelin represents a gold-standard research tool for the precise, reversible modulation of gonadotropin signaling and systemic sex steroid levels.
Frequently Asked Questions
What is the half-life of Triptorelin?
In research models, Triptorelin has a systemic half-life of approximately 3 hours, significantly longer than native GnRH or Gonadorelin.
How should Triptorelin be stored?
Unopened vials should be stored at -20??C. Once mixed with Bacteriostatic Bac.water, keep refrigerated at 2-8??C for up to one week.
Is Triptorelin different from Gonadorelin?
Yes, Triptorelin is far more potent and has a longer half-life, leading to receptor downregulation rather than simple pulsatile stimulation.
Can Triptorelin be used for PCT?
While some researchers use 100mcg micro-doses, its primary function is suppression; improper use can shut down natural production entirely.
What is the appearance of high-purity Triptorelin?
It appears as a pristine white, uniform lyophilized cake that dissolves clearly and quickly upon addition of a sterile diluent.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult a qualified healthcare professional before use.
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