MGF (also known as IGF-1Ec) is a splice variant of the IGF gene which increases stem cell count in the muscle and allows for muscle fibers to fuse and mature. This is a process required for the growth of adult muscle. MGF is produced naturally when muscle fibers are broken down through resistance (weight training). MGF stimulates muscle growth, creates new muscle fibers, promotes muscle recovery, promotes nitrogen retention and increases protein synthesis.
What is MGF (Mechano Growth Factor)?
In studies where MGF was administered intramuscularly, there was a 20% increase in the weight of the injected muscle fibers within 2 weeks. In further studies, it took 4 months for IGF to cause a 25% increase in muscle mass. MGF was found to be more potent than IGF-1 in rapid muscle growth. Fat loss and strength increases are not typically seen with MGF’s use (as they are with IGF-1 use).
How much MGF should be used?
Studies have suggested the following:
A typical protocol would be:
100-300mcg of MGF divided into 1-2 bilateral administrations in 2-5 different areas of the muscles approximately 5-7 days a week – intramuscular injections.
Example, if you want to administer 200mcg of MGF into the chest and biceps muscles 2 times a day and 3 different areas of the muscle then you would need to divided the dose as follows:
200mcg / 2 times per day = 100mcg per administration
100mcg per administration / 4 muscles (2 chest and 2 bicep muscles) = 25mcg per muscle
25mcg per muscle / 3 different locations on each muscle = 8.3mcg per injection
Theoretically, the more locations used to administer the MGF into the muscle the more places for muscle growth.
Studies have also suggested the following:
Administration should not be given within 2 hours after training in order not to reduce natural IGF-1 production.
Administration should not be given within 2 hours before sleeping in order not to reduce natural growth hormone production.
After administering, adequate protein needs to be ingested for MGF to be effective in building new muscle.
How to reconstitute MGF?
MGF is typically manufactured in 2mg amounts and is reconstituted with sterile water.
– If 2ml (2 full – 1 ml U-100 insulin syringe) of sterile water is added to the vial then each unit of the syringe will equal 10mcg.
– If the syringe is filled up to 10 units (up to the number 10 on the syringe) it will equal 100mcg of MGF.
How long should MGF be used?
In most studies on MGF no adverse side effects were reported with use for 4-8 weeks (per the dosage limits in the above answer) followed by 4 weeks of non-use.
What is PEG MGF (pegylated mechano growth factor)?
MGF that’s pegylated, which means it has the addition of Polyethylene glycol – a non toxic additive that increased the half life of MGF from minutes to hours. This means its uses and versatility make it a tremendous addition to a bodybuilders arsenal. I have found it most effective, as its effects are systematic, that means they have a whole body effect wherever muscle has been damaged or is diseased.
How to use PEG-MGF
The next aspect we need to look at is how to make the most use of a long acting version of MGF.
When your muscle is damaged, your body releases a pulse of an MGF splice variant as I outlined above, followed by a less anabolic longer acting version from the liver. Therefore, it seems a waste to inject MGF at this time as you will just blunt your body’s own release, your not enhancing it. So using PEG MGF on non workout days is actually the best route. Since the muscle has been damaged, there are plenty of receptors for MGF, and the effects are systematic. All muscles will be aided in recovery through increased nitrogen retention, protein turnover, and satellite cell activation. Recovery is just going to sky rocket. Doing this means you’re increasing the length of your body’s own mechanism for muscle repair and growth, and you’re opening up the anabolic window.
NOW PLEASE TAKE CAREFUL NOTES.
Running PEG MGF in synergy with IGF is perfect but there are things you need to know. Since IGF has such strong receptor affinity, if you dose them at the same time, the effectiveness of MGF will just be wasted, at least on paper (the science supports this claim). However, further trials that I, and others, have conducted leads this to being inconclusive.
My suggestions for use are as follows
IGF DES on workout days Pre-workout, or IGF1-LR3, this wont blunt your body’s own MGF release from the liver. Whereas IGF1-LR3 has a more systematic effect and only a very small localized anabolic effect, DES on the other hand is very anabolic in a localized way. Therefore, bring up lagging muscle parts with DES, and then the following day Dose MGF at 200-400mcg subq to increase recovery and the mechanism for growth. Perfect synergy.
STORAGE and DOSE
Dosing 3 times a week as suggested above, and 1ml of BA water for every 2mg is optimal. Storage in the fridge for up to 6 months. Avoid exposure to heat or sunlight.